The collections of the Department mainly display exhibits related to the region. The most significant among them are those referring to the history of the 19th-century crafts practiced in Konin, e.g. seal pistons for guilds, insignia of guilds authorities, certificates of craftsmanship and apprenticeship, membership cards of associations, and craft books. Another interesting collection consists of mementos of people significant in the history of Konin, especially Zofia Urbanowska, a positivist writer who wrote for children and the youth; Stefania Łucja Esse, a local gymnasium teacher and an activist for the independence of Poland. A valuable collection is represented by postcards and photographs presenting landscapes of Konin and many other places in the region from the beginning of the 20th century trough the 1960s. Apart from the exhibits mentioned above, the Department also keeps various documents and personal mementos of Konin residents dating back to the Nazi occupation. It is also worth to mention a collection of 70 posters illustrating public life in the town of Koło during the years of the Second Republic of Poland.
In the early 1990s the Department started collecting objects and materials reflecting the political changes in Poland. Many standards of the former communist parties were gathered, namely the standards of the Polish Workers' Party (Polska Partia Robotnicza), the Polish United Workers' Party (Polska Zjednoczona Partia Robotnicza), the Polish Socialist Party (Polska Partia Socjalistyczna), and the Polish Socialist Youth Union (Związek Socjalistycznej Młodzieży Polskiej). Other collected exhibits include: mementos and electoral materials, such as presidential, parliamentary, and local government elections posters.
A separate group of exhibits is a collection of Jewish documents and objects. The most precious among them is the so-called "treasure of Sompolno" consisting of:
1. a plaque placed on a headstone of a Jewish grave (Jan Pogorzelski, Warsaw 1871-1896) with an inscription saying: "In memory of gabajów of the society providing care for the ill, r(abbi) Mendil s(on) of r(abbi) Zelig of b(lissful) m(emory) and r(abbi) Zelman s(on) of r(abbi) Perec of blissful memory 655 (1895) Sompolno";
2. a plaque with an inscription placed on a headstone of a Jewish grave (H.S. Warszawa, the second half of the 19th century);
3. a pair of Rimonim [Literally: pomegranates; decorations on top of wooden rollers of Torah], S.S Warsaw 1880;
4. a pair of Rimonim;
5. three Yad-s [Literally: hand; a hand-shaped pointer used while reading from the Torah scrolls], the second half of the 19th century;
6. a Kiddush Cup [a cup used in a ritual of Jewish Sabbath and other holy days], Kiev 1894, an inscription saying: "To commemorate the s(oul) of Cvi Koniński "gabaj" - Samuel Bibowski.";
7. a saucer bearing the date 662 or 642 (1882 or 1902) and the hardly legible inscription "Sompolno";
8. two candelabra (S.Szkarłat, 1850-1875).

Other exhibits that deserve much attention are a few hundred of fully or partially preserved vertical headstones from destroyed Jewish cemeteries located within the former Konin Province (Turek, Dobra, Golina, Rusocice, Konin). About 500 of these headstones come from Turek; a number of them were made by Henoch Henryk Glicenstein's father in the early 1920s.
The Turek headstones mainly date back to the second half of the 19th century and the years between the two World Wars. The most beautiful among them, representing the Neo-Gothic style of the first half of the 19th century, were probably made in Kalisz. At the end of the 19th century a large scale painting of such headstones began. Traditional symbols - such as candles, broken trees, shelves with books, or rabbi's hands - were painted in bright vivid colors, e.g. red, blue, green, and yellow. Epitaph plaques were mainly covered with black paint and the letters with golden one. The Museum possesses a special computer program for cataloging archive data related to the headstones and the history of the Jewish community of Turek.